HORDB

ID: hor005232
Uniprot ID: Q28605
Protein name: Islet amyloid polypeptide
Gene name: IAPP
Organism: Ovis aries (Sheep)
Family: Calcitonin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Ovis (genus), Caprinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Function: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-Q28605-F1.pdb

hor005232_AF2.pdb

hor005232_ESM.pdb

Mass:	385288	Formula:	C142H232N40O46S2
Absent amino acids:	DHVWY	Common amino acids:	AST
pI:	9.67	Basic residues:	3
Polar residues:	14	Hydrophobic residues:	10
Hydrophobicity:	-11.25	Boman Index:	-3620
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	61.25
Instability Index:	4405	Extinction Coefficient cystines:	0
Absorbance 280nm:	0